| Educational guide Faculty of Chemistry |
english |
| Bachelor's Degree in Biochemistry and Molecular Biology (2009) |
 Subjects |
| GLYCOBIOLOGY |
| Contents |
| IDENTIFYING DATA | 2022_23 |
| Subject | GLYCOBIOLOGY | Code | 13214215 | |||||
| Study programme |
|
Cycle | 1st | |||||
| Descriptors | Credits | Type | Year | Period | ||||
| 3 | Optional | Fourth | 1Q |
|||||
| Competences | Learning outcomes | Contents |
| Planning | Methodologies | Personalized attention |
| Assessment | Sources of information | Recommendations |
| Topic | Sub-topic |
| General principles of glycobiology | The emerging of glycobiology as scientific discipline. Glycobiology and biocomplexity. Structure, nomenclature and structural bases of the diversity of carbohydrates. Conformations and basic reactivity of carbohydrates. Glycosides and glycoconjugates. The representation of glycans. |
| Structure and synthesis of glycoconjugates | Types of glycoconjugates. Biosynthesis, enzymes that process glycans. Glycoproteins. Structure, biosynthesis and function of N-glycans and O-glycans. Proteoglycans: structure and function. Glycolipids, GPI anchors and other glycans. The synthesis of glycoconjugates: strategies and methods. Chemical synthesis in solution, solid-phase synthesis and enzymatic synthesis. |
| Carbohydrate recognition by lectins | Strategies for elucidating the biological functions of glycans. Types of proteins that recognize glycans. Lectins and proteins that recognized GAGs. The mechanisms and general principles of recognition. Multivalence in the recognition of glycans. Methods for determining protein-carbohydrate interactions. Applications of the glycans arrays. Inhibitors of protein (lectin)-carbohydrate interactions. |
| Glycosylation in diseases and physiological processes | Glycoconjugates in the quality control of glycoproteins. Quality control and illness. Glycoconjugates in viral and bacterial infections. Genetic diseases associated with glycans. Inhibitors of glycan-processing enzymes. Glycoconjugates and cancer. The present and future of glycobiology. |
