GENERAL DESCRIPTION OF THE SUBJECT: Computer Science (CS) and Artificial Intelligence (AI) technologies are being incorporated in health care centers for a better treatment of patients. Data-base and knowledge-base technologies are at the core of this revolution. In this course, we will introduce some of the most relevant standards for clinical data codification, data structuration, electronic health records, and semantic annotation. Moreover, the course will introduce notions on data analysis, knowledge representation and management in medicine, and will present decision support systems and artificial intelligence techniques in medicine. The course concludes with an introduction to ethics and security in medical informatics.