| Educational guide Faculty of Chemistry |
english |
| Bachelor's Degree in Biochemistry and Molecular Biology (2009) |
 Subjects |
| GLYCOBIOLOGY |
| Contents |
| IDENTIFYING DATA | 2019_20 |
| Subject | GLYCOBIOLOGY | Code | 13214215 | |||||
| Study programme |
|
Cycle | 1st | |||||
| Descriptors | Credits | Type | Year | Period | ||||
| 3 | Optional | 1Q |
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| Competences | Learning outcomes | Contents |
| Planning | Methodologies | Personalized attention |
| Assessment | Sources of information | Recommendations |
| Topic | Sub-topic |
| General principles of glycobiology | A field of glycobiology. Glycobiology and biocomplexity. Structure, nomenclature and structural bases of the diversity of carbohydrates. Conformations and basic reactivity of carbohydrates. Glycosides and glycoconjugates. The representation of glycans. |
| Structure and synthesis of glycoconjugates | Types of glycoconjugates. Biosynthesis, enzymes that process glycans. Glycoproteins. Structure, biosynthesis and function of N-glycans and O-glycans. Proteoglycans: structure and function. Glycolipids, GPI anchors and other glycans. The synthesis of glycoconjugates: strategies and methods. Chemical synthesis in solution, solid-phase synthesis, and enzymatic synthesis. |
| Carbohydrate recognition by lectins | Strategies for elucidating the biological functions of glycans. Types of proteins that recognize glycans. Lectins and GAGs. The mechanisms and general principles of recognition. Multivalence in the recognition of glycans. Methods for determining protein-carbohydrate interactions. Applications of the arrays of glycans. Inhibitors of protein (lectin)-carbohydrate interactions. |
| Strategies for the structural analysis of glycans | Methods for detecting and visualizing glycans. Purification and chemical derivatization. Instrumental techniques for the structural analysis of glycans (NMR, mass spectrometry, HPLC). The three-dimensional structure of glycans. |
| Glycosylation in diseases and physiological processes | Glycoconjugates in the quality control of glycoproteins. Quality control and illness. Glycoconjugates in viral and bacterial infections. Genetic diseases associated with glycans. Inhibitors of glycan-processing enzymes. Glycoconjugates and cancer. Glycoconjugates and parasitic diseases. The present and future of glycobiology. |
